Antibodies against Defined Nerve Cell Components: Gangliosides
نویسندگان
چکیده
منابع مشابه
Antibodies against GM1 gangliosides associated with metastatic melanoma.
The aim was to analyze humoral immune response against GM1 ganglioside expressed on the surface of melanocytic cells, and the possible correlation between the level of antibodies against GM1 IgG and IgM class and melanoma progression. The study included 128 adult patients with malignant melanoma, without paraneoplastic neurologic disorders, 48 adults with dysplastic nevi and 48 healthy voluntee...
متن کاملLipid Components of Gangliosides.
The fatty acids and the long-chain bases of gangliosides from several sources were analyzed by means of gas-liquid chromatography. Stearic acid was found to be the major fatty acid component while palmitic and arachidic acids were found in small amounts, confirming previous observations. Hydroxy acids were not found in any significant amounts. In addition to sphingosine and a small amount of di...
متن کاملMonoclonal antibodies raised against Guillain-Barré syndrome-associated Campylobacter jejuni lipopolysaccharides react with neuronal gangliosides and paralyze muscle-nerve preparations.
Guillain-Barré syndrome and its variant, Miller-Fisher syndrome, are acute, postinfectious, autoimmune neuropathies that frequently follow Campylobacter jejuni enteritis. The pathogenesis is believed to involve molecular mimicry between sialylated epitopes on C. jejuni LPSs and neural gangliosides. More than 90% of Miller-Fisher syndrome cases have serum anti-GQ1b and anti-GT1a ganglioside anti...
متن کاملGangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration.
Myelin-associated glycoprotein (MAG) binds to the nerve cell surface and inhibits nerve regeneration. The nerve cell surface ligand(s) for MAG are not established, although sialic acid-bearing glycans have been implicated. We identify the nerve cell surface gangliosides GD1a and GT1b as specific functional ligands for MAG-mediated inhibition of neurite outgrowth from primary rat cerebellar gran...
متن کاملSerum antibodies against gangliosides and Campylobacter jejuni lipopolysaccharides in Miller Fisher syndrome.
Seven patients with Miller Fisher syndrome (MFS), six in the acute phase and one in the recovery phase, were investigated for serum antibodies against gangliosides and purified lipopolysaccharides (LPS) from different strains of Campylobacter jejuni, including the MFS-associated serotypes O:2 and O:23. Immunoglobulin G antibodies against gangliosides GT1a and GQ1b were found in five of six pati...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1980
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107688007300707